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migración de leucocito The movement of a leukocyte within or between different tissues and organs of the body.
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Arhgef1 is a hematopoietic-restricted signaling molecule that regulates leukocyte migration and integrin-mediated adhesion.
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Background: Chemokines bind to specific receptors and mediate leukocyte migration to sites of inflammation.
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The acidification did not interfere in leukocyte migration under agar.
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Our results establish a causative role for negative regulators of leukocyte migration in chronic inflammation.
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In addition, Ang-2 exerted a weak stimulatory effect on leukocyte migration in the mouse paw.
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The immune suppressive mechanisms of Tregs include contact-dependent, cytokine secretion and regulation of immune cell migration.
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Proliferation is necessary for EC-CFU generation; however, colony growth also occurs as a result of leucocyte migration.
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Corticosteroid treatment did not exert a major effect on leucocyte migration, though the doses involved were relatively small.
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Serial studies of leucocyte migration in vivo were carried out in 15 patients with Behçet's syndrome using a skin window technique.
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However, the role of S1P receptors in normal immune cell trafficking is unclear.
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APT reduced intrahepatic platelet accumulation and the frequency of platelet- immune cell interaction, thereby limiting hepatic immune cell trafficking.
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In conclusion, the DIV-BBBr represents the most realistic in vitro system to study the immune cell trafficking across the BBB.
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Lymphatic vessels play physiological roles relevant to all medical fields as important regulators of fluid balance, immune cell trafficking, and immune identity.
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Immune cell trafficking is orchestrated by a family of small proteins called chemokines.
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The innate mechanisms driving (or inhibiting) leukocyte trafficking to allografts remain incompletely understood.
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We now show that aldosterone triggers endothelial cell exocytosis, the first step in leukocyte trafficking.
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Our data show that antibody to host antigens can activate human endothelial cell exocytosis and leukocyte trafficking.
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We hypothesized that endothelial expression of such guidance cues may regulate leukocyte trafficking into the vascular wall during atherogenesis.
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Uveitis was assessed using intravital videomicroscopy, which visualizes leukocyte trafficking within the vasculature and tissue of the iris, and by histology.
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In vivo microscopy of leukocyte trafficking was performed in non-thrombosed mice, and tissue and plasma were harvested during early VT formation.
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These data indicate a previously unappreciated role for axonal guidance cues in maintaining the endothelial barrier and regulating leukocyte trafficking during atherogenesis.
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Importantly, in healthy neonates, blocking TNF-a at birth disrupted the physiologic leukocyte trafficking, which resulted in persistently altered leukocyte profiles at barrier sites.
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First thought to orchestrate exclusively leukocyte trafficking, chemokines are now acknowledged for their multiple roles in the regulation of cell proliferation, differentiation, and survival.
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The drug's activity is based on an improved permeabilization of newly formed tumor vasculature, which favors intratumor penetration of chemotherapeutic agents and leukocyte trafficking.
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Leukocyte trafficking and recruitment is a critical process in host immune surveillance and in inflammatory diseases.
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Leukocyte trafficking into the CNS is a prominent feature driving the immunopathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis.